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01/26/2016

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02/13/2013

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Clinical Study Highlights

Clinical validations of DynaPulse central blood pressure readings, systolic, diastolic and mean arterial pressure (MAP), pressure waveform, and arterial compliance vs. invasive catheterization measurement values - "Development and Validation of a Noninvasive Method to Determine Arterial Pressure and Vascular Compliance", by TJ Brinton, AN DeMarial, et. al, Am. J. Cardiology 1997; 80:323-330


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Clinical applications of DynaPulse arterial compliance to hypertension care - "Arterial Compliance by Cuff Sphygmomanometer, Application to Hypertension and Early Changes in Subjects at Genetic Risk",

by TJ Brinton, DT O'connor, et. al., Hypertension. 1996; 28:599-603


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Clinical validation of DynaPulse cardiac output measurement - "Development and Validation of a Noninvasive Method to Estimate Cardiac Output using Cuff Sphygmomanometry", by SS Chio, AN Demaria, et. al., Clin. Cardiology 2007; 30:615-620


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Validations of DynaPulse Korotkoff sound blood pressure readings, K1, K4 and K5, vs. auscultatory measurement - "Korotkoff sound versus Oscillometric Cuff Sphygmomanometers: Comparison between Auscultatory and DynaPulse Blood pressure Measurements", by SS Chio, GS Berenson, et. al., J. Am. Society of Hypertension 2011; 5(1):12-20


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Validation of DynaPulse blood pressure measurement vs. American National Standard Institute/ Association for the Advancement of Medical Instrument (ANSI/AAMI) Guideline - "Validation of Pulse Dynamic Blood Pressure measurement by Auscultation", by TJ Brinton, et. al., 1998; 3:121-124


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Application of DynaPulse in clinical study on Pre-hypertension - "Autonomic and Hemodynamic, Origins of Pre-hypertension - Central Role of Heredity", by JT Davis, DT O'Connor, et. al., J. Am. College of Cardiology, 2012; 59(24):2206-2216


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Application of DynaPulse in study on PTSD - "Predictors of Risk and Resilience for Posttraumatic Stress Disorder Among Ground Combat Marines: Methods of the Marine Resiliency Study", by DG Baker, DT O'Connor, et. al., CDC publication, preventing chronic disease, 2012; 9:110134


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Application of DynaPulse in study on cardiovascular health in young adults - "Relationship between Elevated Arterial Stiffness and Increased Left Ventricular Mass in Adolescents and Young Adults", by EM Urbina, et. al., J Pediatr. 2011;158:715-21


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Application of DynaPulse in study on cardiovascular health of pre-hypertension in youth - "Cardiac and Vascular Consequences of Pre-Hypertension in Youth", by EM Urbina, et. al., J Clin Hypertens (Greenwich). 2011;13: 332342


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Application of DynaPulse in study on cardiovascular health vs. obesity and type-2 diabetes - "Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitus", by EM Urbina, et. al., Journal of Hypertension 2010, 28:16921698


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DynaPulse contributed to studies on cardiovascular diseases and diabetes - "Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus, A Scientific Statement From the American Heart Association (AHA)", by DM Maahs, EU Urbina, et. al., Circulation. 2014;130:1532-1558


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DynaPulse contributed to studies on cardiovascular risk assessment - "Noninvasive Assessment of Subclinical Atherosclerosis in Children and Adolescents - Recommendations for Standard Assessment for Clinical Research: A Scientific Statement From the American Heart Association", by EM Urbina, et. al., Hypertension. 2009; 54:919-950


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Application of DynaPulse as an easier, safer and cost effective method, compare to EBCT scanning, for evaluation coronary calcification, a cause of heart attack - "Measures of Brachial Artery Distensibility in Relation to Coronary Calcification", by MJ Budoff, et. al., American Journal of Hypertension 2003; 16:350355


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Application of DynaPulse in environmental research on cardiovascular health - "Polycyclic aromatic hydrocarbons, brachial artery distensibility and blood pressure among children residing near an oil refinery", by L Trasande, EM Urbina, et. al., Environmental Research 136 (2015) 133140


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Application of DynaPulse in study on air pollution and cardiovascular health - "Progress of Ambient Air Pollution and Cardiovascular Disease Research in Asia", by TC Su, et. al., Progress in Cardiovascular Diseases 53 (2011) 369378


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Application of DynaPulse in study on work related heart disease - "Working hours, sleep duration and the risk of acute coronary heart disease: A case-control study of middle-agged men in Taiwan", by YW Cheng, TC Su, et. al., International J. of Cardiology, 2014; 171:419-422


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DynaPulse 24-hour ambulatory blood pressure and arterial distensibility and compliance measurement contributed to the research and development of combination drug therapy for hypertension treatments - "Effect of Antihypertensive Monotherapy and Combination Therapy on Arterial Distensibility and Left Ventricular Mass", by JM. Neutel, MA Weber, et. al., 2004; Am J Hypertens 17:3742


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Application of DynaPulse in study on cardiovascular health vs. lifestyle - " Effects of Anxiety and Depression on Arterial Elasticity of Subjects With Sub-optimal Physical Health", by NL Sun, et. al., Clin. Cardiology, 2015; 38(10):614620



 

Patents

Chio, SS, Method and apparatus for diagnosing conditions using tissue color (US patent #8,009,884 B2, Aug. 30, 2011)


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Chio, SS, Method for Diagnosing, Monitoring and Treating Hypertension and other Cardiac Problems, US Patents #6,540,687 B2, (2003), #6270461 (2001), #6165130 (2000) and #5836884 (1998); China Patent # ZL94-1-94512, Oct. 8, 2003; Canadian Patent # 2,177,842, Jan., 6, 2004.


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Chio, SS and Brinton TJ, Non-invasive Method and Apparatus for Diagnosing and Monitoring Aortic Valve Abnormalities, Such as Aortic Regurgitation, US Patent #RE38,159 E, Jun. 24, 2003 and #5879307, March 9, 1999.


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Chio, SS, Method for Diagnosing, Monitoring and Treating Hypertension and other Cardiac Problems, US Patent # 5836884, Nov. 17, 1998.


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Chio SS. Method and Apparatus for Determining Blood Pressure and Cardiovascular Conditions: US Patent #4880013, 1989; Taiwan, R.O.C. Patent #40711, 1990; European Patent # 0365614, 1995, Japan Patent # 2098991, 1998.


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Chio SS. Turning of A Heart Pacemaker Through the Use of Blood Pressure and Cardiovascular Readings, US Patent #5162991, 1992